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KMID : 0604520060320040219
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Journal of the Society of Cosmetic Scientists of Korea
2006 Volume.32 No. 4 p.219 ~ p.225
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Inhibitory Effect of Melanogenesis and Anti-inflammatory Effect of Elsholtzia ciliata Extract and Its Application as a Cosmeceutical Ingredient
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Lee Dae-Woo
Kim Young-Jin
Kim Young-Sil
Eom Sang-Yong
Kim Jong-Heon
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Abstract
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In this study, we evaluated anti-oxidation, whitening and anti-inflammatory effects of Elsholtzia ciliata extract for use as the cosmeceuticals. Elsholtzia ciliata extracts (30, 70 and 100% methanol extract) exhibited a significant tree radical scavenging effect (up to 80% over 0.025% concentration of 30 and 70% methanol extract, over 0.01% concentration of 100% methanol extract) against DPPH radical generation and showed a significant inhibitory effect (up to 80% over 0.1% concentration) on melanin synthesis in B-16 Melanoma cells. We separated 4 fractions from Elsholtzia ciliata extract (70% methanol extract) by MPLC. The 1st, 2nd, and 3rd fractions showed anti-oxidation (DPPH radical scavenging activity and suppressive effect on Mn-SOD), whitening(inhibitory effect on melanin synthesis) and anti-inflammatory (suppressive effects on IL-1{alpha}, IL-6, COX-2, and total NO synthesis) effects.
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KEYWORD
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Elsholtzia ciliata, anti-oxidation, melanogenesis, anti-inflammation, IL-1{\alpha}
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